Nature Biotechnology Contents: Volume 32 pp 700 - 960

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Advertisement Advertisement Transfect with Confidence using X-tremeGENE Reagents from Roche Efficiently transfect DNA or siRNA to power your cell-based applications Obtain high numbers of healthy, viable cells Achieve high transfection efficiency Generate high recombinant protein yields Minimize cytotoxicity and off-target effects Assess true cell response rather than the effects of your transfection reagents Generate physiologically relevant data by minimizing reagent-induced changes  To learn more, please visit: X-tremeGENE.roche.com TABLE OF CONTENTS September 2014 Volume 32, Issue 9 In This Issue Editorial News Bioentrepreneur Opinion and Comment Features News and Views Computational Biology Research Careers and Recruitment Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement BIOPHARMA DEALMAKERS Company Profiles and Partnering Opportunities   Advertisement Nature Biotechnology  ANIMATION: ANTIBODY-DRUG CONJUGATES The challenges facing targeted delivery of antibody-drug conjugates to a tumor are presented in a 3D animation that describes some of the mechanisms by which these agents target cells. Animation by Nucleus Inc. Produced with support from  Daiichi Sankyo and Takeda Pharmaceuticals     Focus on RNA sequencing quality control (SEQC Contents In This Issue Editorial News and Views Computational Biology Research Research in regenerative medicine is advancing toward the goal of repairing damaged tissue and organs. Nature Biotechnology and Nature Medicine present a collection of reviews, features and commentaries that explore our current mechanistic understanding of stem cells, and the emerging technologies that will bring regenerative medicine to the clinic. Top In This Issue Top Focus on RNA sequencing quality control (SEQC)   ppvii - vii doi:10.1038/nbt.3025 Editorial Top Honing our reading skills   p845 doi:10.1038/nbt.3021 Studies from the RNA Sequencing Quality Control (SEQC) initiative exemplify the kind of experimental groundwork needed to expand RNA-seq into a broader array of basic and translational applications. News Top First PD-1 inhibitor breezes across finish line   pp847 - 848 Cormac Sheridan doi:10.1038/nbt0914-847 Organs-on-chips Harvard spinout   p849 doi:10.1038/nbt0914-849b Roche snaps up RNA-medicines firm Santaris   p849 doi:10.1038/nbt0914-849c Rabbit milk Ruconest for hereditary angioedema   p849 doi:10.1038/nbt0914-849d Biotech drugs too little, too late for Ebola outbreak   pp849 - 850 Stephen Strauss doi:10.1038/nbt0914-849a CAR-T cell therapy gets breakthrough status   p851 doi:10.1038/nbt0914-851b NCATs drug candidate attracts first buyer   p851 doi:10.1038/nbt0914-851c Sanofi to propel inhalable insulin Afrezza into market   pp851 - 852 Jim Kling doi:10.1038/nbt0914-851a First-in-class BTK inhibitor Imbruvica gets CLL approval   p852 doi:10.1038/nbt0914-852a Google Ventures launches London office   p852 doi:10.1038/nbt0914-852b Small biotech steers HDAC inhibitor to clinic   pp853 - 854 Mark Ratner doi:10.1038/nbt0914-853 Around the world in a month   p854 doi:10.1038/nbt0914-854 FDA pushes for control over laboratory-developed tests   p855 Mark Ratner doi:10.1038/nbt0914-855a Bioelectronics SPARC at NIH   p855 doi:10.1038/nbt0914-855b First biosimilars trickle into US pathway   p855 doi:10.1038/nbt0914-855c Novartis signs up for Google smart lens   p856 Melanie Senior doi:10.1038/nbt0914-856 Vitamin A Super Banana in human trials   p857 Emily Waltz doi:10.1038/nbt0914-857 RAC to finally relax gene therapy oversight   p858 Asher Mullard doi:10.1038/nbt0914-858 News Feature Stepping into the sunshine   pp859 - 862 Charles Schmidt doi:10.1038/nbt.3008 Is the imminent release of the database of industry's 'gifts' to doctors cause for concern or celebration? Charles Schmidt investigates. Advertisement Nobel Laureate to Give Keynote Address at The International Symposium for Tissue Phenomics™ Hear Dr. Gerd Binnig, Nobel Laureate, Founder, and Chief Technology Officer at Definiens, present on Tissue Phenomics™ and how tissue images can be turned into big data for robust correlation to clinical outcomes. Register today to join us October 17-18 in San Francisco. Bioentrepreneur Top Building a business Building a curriculum for bioentrepreneurs   pp863 - 865 Lynn Johnson Langer doi:10.1038/nbt.3012 SciCafé Startups on the menu: Alnylam   p866 doi:10.1038/nbt.3009 Opinion and Comment Top Correspondence OpenBiome remains open to serve the medical community   p867 Mark Smith, Zain Kassam, Carolyn Edelstein, James Burgess and Eric Alm doi:10.1038/nbt.3006 Field trial of Xanthomonas wilt disease-resistant bananas in East Africa   pp868 - 870 Leena Tripathi, Jaindra Nath Tripathi, Andrew Kiggundu, Sam Korie, Frank Shotkoski et al. doi:10.1038/nbt.3007 Commentary Scientific rigor and the art of motorcycle maintenance   pp871 - 873 Marcus Munafo, Simon Noble, William J Browne, Dani Brunner, Katherine Button et al. doi:10.1038/nbt.3004 The reliability of scientific research is under scrutiny. A recently convened working group proposes cultural adjustments to incentivize better research practices. The special case of gene therapy pricing   pp874 - 876 Troyen A Brennan and James M Wilson doi:10.1038/nbt.3003 Gene therapy companies that pursue high, one-time payments for their products risk a backlash from payors. A better solution may lie in a pay-for-performance model. Features Top Patents Patents or patients: who loses?   pp877 - 880 Joanna Brougher and Konstantin M Linnik doi:10.1038/nbt.3005 The unprecedented weakening of patent rights in the United States undermines necessary incentives for the discovery and development of innovative medicines. Recent patent applications in differential gene expression   p881 doi:10.1038/nbt.3023 News and Views Top The devil in the details of RNA-seq   pp882 - 884 Anton Kratz and Piero Carninci doi:10.1038/nbt.3015 Large-scale consortium efforts provide a thorough understanding of RNA-seq. See also: Computational Biology by Li et al. | Computational Biology by Risso et al. | SEQC/MAQC-III Consortium | Research by Li et al. | Research by Wang et al. Bringing RNA-seq closer to the clinic   pp884 - 885 Kendall Van Keuren-Jensen, Jonathan J Keats and David W Craig doi:10.1038/nbt.3017 Several multicenter benchmark data sets represent valuable steps toward using RNA-seq as a diagnostic tool with clinical utility. See also: Computational Biology by Li et al. | Computational Biology by Risso et al. | SEQC/MAQC-III Consortium | Research by Li et al. | Research by Wang et al. Research Highlights   p885 doi:10.1038/nbt.3014 Wheat rescued from fungal disease   pp886 - 887 Javier Gil-Humanes and Daniel F Voytas doi:10.1038/nbt.3013 Knockout of all six alleles of a gene in the large wheat genome confers resistance to powdery mildew. See also: Research by Wang et al. New plant species through grafting   p887 Peter Hare doi:10.1038/nbt.3010 Biotechnology JOBS of the week Postdoctoral Positions in Natural Product Pharmacology and Biochemistry Vanderbilt University Medical Center Assistant or Associate Professor - Department of Biochemistry Boston University School of Medicine, BUMC Assistant Professor- Biology / Biochemistry University of British Columbia (UBC) Postdoc - Bioinformatics Stanford University School of Medicine Postdoctoral Fellow in Bioinformatics and Computational Biology Bioinformatics Institute (BII) More Science jobs from Biotechnology EVENT Biosensors: Applications in Industrial Biotechnology October 21, 2014 London, UK More science events from Computational Biology Top Analysis Detecting and correcting systematic variation in large-scale RNA sequencing data   pp888 - 895 Sheng Li, Pawel P Labaj, Paul Zumbo, Peter Sykacek, Wei Shi et al. doi:10.1038/nbt.3000 Li et al. identify the top-performing methods to improve cross-site differential gene expression analysis with RNA-seq. See also: News and Views by Kratz & Carninci | News and Views by Van Keuren-Jensen et al. Normalization of RNA-seq data using factor analysis of control genes or samples   pp896 - 902 Davide Risso, John Ngai, Terence P Speed and Sandrine Dudoit doi:10.1038/nbt.2931 Remove unwanted variation (RUV) is a new statistical method for RNA-seq data normalization that uses control genes or samples to improve differential expression analysis. See also: News and Views by Kratz & Carninci | News and Views by Van Keuren-Jensen et al. Research Top Articles A comprehensive assessment of RNA-seq accuracy, reproducibility and information content by the Sequencing Quality Control Consortium   pp903 - 914 Zhenqiang Su, Pawel P Labaj, Sheng Li, Jean Thierry-Mieg, Danielle Thierry-Mieg et al. doi:10.1038/nbt.2957 The Sequencing Quality Control (SEQC) consortium shows that junction discovery and differential gene expression profiling with RNA-seq can be robust but transcript-level and absolute measurements remain challenging. See also: News and Views by Kratz & Carninci | News and Views by Van Keuren-Jensen et al. Multi-platform assessment of transcriptome profiling using RNA-seq in the ABRF next-generation sequencing study   pp915 - 925 Sheng Li, Scott W Tighe, Charles M Nicolet, Deborah Grove, Shawn Levy et al. doi:10.1038/nbt.2972 For intact RNA, gene expression profiles from rRNA-depletion and poly-A enrichment are similar. In addition, rRNA- depletion enables effective analysis of degraded RNA samples. See also: News and Views by Kratz & Carninci | News and Views by Van Keuren-Jensen et al. The concordance between RNA-seq and microarray data depends on chemical treatment and transcript abundance   pp926 - 932 Charles Wang, Binsheng Gong, Pierre R Bushel, Jean Thierry-Mieg, Danielle Thierry-Mieg et al. doi:10.1038/nbt.3001 A comparison of RNA-seq and microarray data from samples treated with diverse drugs highlights a dependency of cross-platform concordance on treatment effect. See also: News and Views by Kratz & Carninci | News and Views by Van Keuren-Jensen et al. Revealing long noncoding RNA architecture and functions using domain-specific chromatin isolation by RNA purification   pp933 - 940 Jeffrey J Quinn, Ibrahim A Ilik, Kun Qu, Plamen Georgiev, Ci Chu et al. doi:10.1038/nbt.2943 Domain-specific chromatin isolation by RNA purification (dChIRP) identifies interacting partners of functional regions of long noncoding RNAs. Letters Generation of mouse models of myeloid malignancy with combinatorial genetic lesions using CRISPR-Cas9 genome editing   pp941 - 946 Dirk Heckl, Monika S Kowalczyk, David Yudovich, Roger Belizaire, Rishi V Puram et al. doi:10.1038/nbt.2951 The genetic complexity of human leukemia is modeled using the CRISPR-Cas9 system in mice. Simultaneous editing of three homoeoalleles in hexaploid bread wheat confers heritable resistance to powdery mildew   pp947 - 951 Yanpeng Wang, Xi Cheng, Qiwei Shan, Yi Zhang, Jinxing Liu et al. doi:10.1038/nbt.2969 TALEN-induced mutation of all homologous copies of a gene that represses resistance to an important wheat pathogen confers a trait that has eluded plant breeders for decades. See also: News and Views by Gil-Humanes & Voytas Errata Erratum: HIV immunity goes direct   p952 doi:10.1038/nbt0914-952a Erratum: University biotech patenting 2013   p952 Brady Huggett and Kathryn Paisner doi:10.1038/nbt0914-952b Erratum: In Their Words   p952 doi:10.1038/nbt0914-952c Corrigendum Corrigendum: Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype   p952 Hao Yin, Wen Xue, Sidi Chen, Roman L Bogorad, Eric Benedetti et al. doi:10.1038/nbt0914-952d Careers and Recruitment Top Mobility, retention and productivity of genomics scientists in the United States   pp953 - 958 Kenneth Guang-Lih Huang and Gokhan Ertug doi:10.1038/nbt.3016 The United States appears to have an increasingly weakening ability to attract and retain genomics scientists. People People   p960 doi:10.1038/nbt.3024 Top Advertisement Wellcome Trust and Nature Genetics present: The Genomics of Common Diseases 2014 September 17-20, 2014 Bolger Center, Potomac, MD, USA Click here for more information to register for this conference today!   Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/myaccount (You will need to log in to be recognised as a nature.com registrant) For further technical assistance, please contact our registration department For print subscription enquiries, please contact our subscription department For other enquiries, please contact our customer feedback department Nature Publishing Group | 75 Varick Street, 9th Floor | New York | NY 10013-1917 | USA Nature Publishing Group's worldwide offices: London - Paris - Munich - New Delhi - Tokyo - Melbourne San Diego - San Francisco - Washington - New York - Boston Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at Brunel Road, Houndmills, Basingstoke, Hampshire RG21 6XS. © 2014 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.

Transfect with Confidence using X-tremeGENE Reagents from Roche Efficiently transfect DNA or siRNA to power your cell-based applications Obtain high numbers of healthy, viable cells Achieve high transfection efficiency Generate high recombinant protein yields Minimize cytotoxicity and off-target effects Assess true cell response rather than the effects of your transfection reagents Generate physiologically relevant data by minimizing reagent-induced changes To learn more, please visit: X-tremeGENE.roche.com

TABLE OF CONTENTS

---

September 2014 Volume 32, Issue 9

In This Issue
Editorial
News
Bioentrepreneur
Opinion and Comment
Features
News and Views
Computational Biology
Research
Careers and Recruitment

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Recommend to library		Twitter

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Nature Biotechnology  ANIMATION: ANTIBODY-DRUG CONJUGATES The challenges facing targeted delivery of antibody-drug conjugates to a tumor are presented in a 3D animation that describes some of the mechanisms by which these agents target cells. Animation by Nucleus Inc. Produced with support from  Daiichi Sankyo and Takeda Pharmaceuticals

 

Focus on RNA sequencing quality control (SEQC
	Contents In This Issue Editorial News and Views Computational Biology Research
Research in regenerative medicine is advancing toward the goal of repairing damaged tissue and organs. Nature Biotechnology and Nature Medicine present a collection of reviews, features and commentaries that explore our current mechanistic understanding of stem cells, and the emerging technologies that will bring regenerative medicine to the clinic.

Top

In This Issue

Top

Focus on RNA sequencing quality control (SEQC)   ppvii - vii
doi:10.1038/nbt.3025

Editorial

Top

Honing our reading skills   p845
doi:10.1038/nbt.3021
Studies from the RNA Sequencing Quality Control (SEQC) initiative exemplify the kind of experimental groundwork needed to expand RNA-seq into a broader array of basic and translational applications.

News

Top

First PD-1 inhibitor breezes across finish line   pp847 - 848
Cormac Sheridan
doi:10.1038/nbt0914-847

Organs-on-chips Harvard spinout   p849
doi:10.1038/nbt0914-849b

Roche snaps up RNA-medicines firm Santaris   p849
doi:10.1038/nbt0914-849c

Rabbit milk Ruconest for hereditary angioedema   p849
doi:10.1038/nbt0914-849d

Biotech drugs too little, too late for Ebola outbreak   pp849 - 850
Stephen Strauss
doi:10.1038/nbt0914-849a

CAR-T cell therapy gets breakthrough status   p851
doi:10.1038/nbt0914-851b

NCATs drug candidate attracts first buyer   p851
doi:10.1038/nbt0914-851c

Sanofi to propel inhalable insulin Afrezza into market   pp851 - 852
Jim Kling
doi:10.1038/nbt0914-851a

First-in-class BTK inhibitor Imbruvica gets CLL approval   p852
doi:10.1038/nbt0914-852a

Google Ventures launches London office   p852
doi:10.1038/nbt0914-852b

Small biotech steers HDAC inhibitor to clinic   pp853 - 854
Mark Ratner
doi:10.1038/nbt0914-853

Around the world in a month   p854
doi:10.1038/nbt0914-854

FDA pushes for control over laboratory-developed tests   p855
Mark Ratner
doi:10.1038/nbt0914-855a

Bioelectronics SPARC at NIH   p855
doi:10.1038/nbt0914-855b

First biosimilars trickle into US pathway   p855
doi:10.1038/nbt0914-855c

Novartis signs up for Google smart lens   p856
Melanie Senior
doi:10.1038/nbt0914-856

Vitamin A Super Banana in human trials   p857
Emily Waltz
doi:10.1038/nbt0914-857

RAC to finally relax gene therapy oversight   p858
Asher Mullard
doi:10.1038/nbt0914-858

News Feature

Stepping into the sunshine   pp859 - 862
Charles Schmidt
doi:10.1038/nbt.3008
Is the imminent release of the database of industry's 'gifts' to doctors cause for concern or celebration? Charles Schmidt investigates.

Advertisement

Nobel Laureate to Give Keynote Address at The International Symposium for Tissue Phenomics™ Hear Dr. Gerd Binnig, Nobel Laureate, Founder, and Chief Technology Officer at Definiens, present on Tissue Phenomics™ and how tissue images can be turned into big data for robust correlation to clinical outcomes. Register today to join us October 17-18 in San Francisco.

Bioentrepreneur

TopBuilding a business

Building a curriculum for bioentrepreneurs   pp863 - 865
Lynn Johnson Langer
doi:10.1038/nbt.3012

SciCafé

Startups on the menu: Alnylam   p866
doi:10.1038/nbt.3009

Opinion and Comment

TopCorrespondence

OpenBiome remains open to serve the medical community   p867
Mark Smith, Zain Kassam, Carolyn Edelstein, James Burgess and Eric Alm
doi:10.1038/nbt.3006

Field trial of Xanthomonas wilt disease-resistant bananas in East Africa   pp868 - 870
Leena Tripathi, Jaindra Nath Tripathi, Andrew Kiggundu, Sam Korie, Frank Shotkoski et al.
doi:10.1038/nbt.3007

Commentary

Scientific rigor and the art of motorcycle maintenance   pp871 - 873
Marcus Munafo, Simon Noble, William J Browne, Dani Brunner, Katherine Button et al.
doi:10.1038/nbt.3004
The reliability of scientific research is under scrutiny. A recently convened working group proposes cultural adjustments to incentivize better research practices.

The special case of gene therapy pricing   pp874 - 876
Troyen A Brennan and James M Wilson
doi:10.1038/nbt.3003
Gene therapy companies that pursue high, one-time payments for their products risk a backlash from payors. A better solution may lie in a pay-for-performance model.

Features

TopPatents

Patents or patients: who loses?   pp877 - 880
Joanna Brougher and Konstantin M Linnik
doi:10.1038/nbt.3005
The unprecedented weakening of patent rights in the United States undermines necessary incentives for the discovery and development of innovative medicines.

Recent patent applications in differential gene expression   p881
doi:10.1038/nbt.3023

News and Views

Top

The devil in the details of RNA-seq   pp882 - 884 Anton Kratz and Piero Carninci doi:10.1038/nbt.3015 Large-scale consortium efforts provide a thorough understanding of RNA-seq. See also: Computational Biology by Li et al. | Computational Biology by Risso et al. | SEQC/MAQC-III Consortium | Research by Li et al. | Research by Wang et al. Bringing RNA-seq closer to the clinic   pp884 - 885 Kendall Van Keuren-Jensen, Jonathan J Keats and David W Craig doi:10.1038/nbt.3017 Several multicenter benchmark data sets represent valuable steps toward using RNA-seq as a diagnostic tool with clinical utility. See also: Computational Biology by Li et al. | Computational Biology by Risso et al. | SEQC/MAQC-III Consortium | Research by Li et al. | Research by Wang et al. Research Highlights   p885 doi:10.1038/nbt.3014 Wheat rescued from fungal disease   pp886 - 887 Javier Gil-Humanes and Daniel F Voytas doi:10.1038/nbt.3013 Knockout of all six alleles of a gene in the large wheat genome confers resistance to powdery mildew. See also: Research by Wang et al. New plant species through grafting   p887 Peter Hare doi:10.1038/nbt.3010

Biotechnology JOBS of the week Postdoctoral Positions in Natural Product Pharmacology and Biochemistry Vanderbilt University Medical Center Assistant or Associate Professor - Department of Biochemistry Boston University School of Medicine, BUMC Assistant Professor- Biology / Biochemistry University of British Columbia (UBC) Postdoc - Bioinformatics Stanford University School of Medicine Postdoctoral Fellow in Bioinformatics and Computational Biology Bioinformatics Institute (BII) More Science jobs from Biotechnology EVENT Biosensors: Applications in Industrial Biotechnology October 21, 2014 London, UK More science events from

Computational Biology

TopAnalysis

Detecting and correcting systematic variation in large-scale RNA sequencing data   pp888 - 895
Sheng Li, Pawel P Labaj, Paul Zumbo, Peter Sykacek, Wei Shi et al.
doi:10.1038/nbt.3000
Li et al. identify the top-performing methods to improve cross-site differential gene expression analysis with RNA-seq.

See also: News and Views by Kratz & Carninci | News and Views by Van Keuren-Jensen et al.

Normalization of RNA-seq data using factor analysis of control genes or samples   pp896 - 902
Davide Risso, John Ngai, Terence P Speed and Sandrine Dudoit
doi:10.1038/nbt.2931
Remove unwanted variation (RUV) is a new statistical method for RNA-seq data normalization that uses control genes or samples to improve differential expression analysis.

See also: News and Views by Kratz & Carninci | News and Views by Van Keuren-Jensen et al.

Research

TopArticles

A comprehensive assessment of RNA-seq accuracy, reproducibility and information content by the Sequencing Quality Control Consortium   pp903 - 914
Zhenqiang Su, Pawel P Labaj, Sheng Li, Jean Thierry-Mieg, Danielle Thierry-Mieg et al.
doi:10.1038/nbt.2957
The Sequencing Quality Control (SEQC) consortium shows that junction discovery and differential gene expression profiling with RNA-seq can be robust but transcript-level and absolute measurements remain challenging.

See also: News and Views by Kratz & Carninci | News and Views by Van Keuren-Jensen et al.

Multi-platform assessment of transcriptome profiling using RNA-seq in the ABRF next-generation sequencing study   pp915 - 925
Sheng Li, Scott W Tighe, Charles M Nicolet, Deborah Grove, Shawn Levy et al.
doi:10.1038/nbt.2972
For intact RNA, gene expression profiles from rRNA-depletion and poly-A enrichment are similar. In addition, rRNA- depletion enables effective analysis of degraded RNA samples.

See also: News and Views by Kratz & Carninci | News and Views by Van Keuren-Jensen et al.

The concordance between RNA-seq and microarray data depends on chemical treatment and transcript abundance   pp926 - 932
Charles Wang, Binsheng Gong, Pierre R Bushel, Jean Thierry-Mieg, Danielle Thierry-Mieg et al.
doi:10.1038/nbt.3001
A comparison of RNA-seq and microarray data from samples treated with diverse drugs highlights a dependency of cross-platform concordance on treatment effect.

See also: News and Views by Kratz & Carninci | News and Views by Van Keuren-Jensen et al.

Revealing long noncoding RNA architecture and functions using domain-specific chromatin isolation by RNA purification   pp933 - 940
Jeffrey J Quinn, Ibrahim A Ilik, Kun Qu, Plamen Georgiev, Ci Chu et al.
doi:10.1038/nbt.2943
Domain-specific chromatin isolation by RNA purification (dChIRP) identifies interacting partners of functional regions of long noncoding RNAs.

Letters

Generation of mouse models of myeloid malignancy with combinatorial genetic lesions using CRISPR-Cas9 genome editing   pp941 - 946
Dirk Heckl, Monika S Kowalczyk, David Yudovich, Roger Belizaire, Rishi V Puram et al.
doi:10.1038/nbt.2951
The genetic complexity of human leukemia is modeled using the CRISPR-Cas9 system in mice.

Simultaneous editing of three homoeoalleles in hexaploid bread wheat confers heritable resistance to powdery mildew   pp947 - 951
Yanpeng Wang, Xi Cheng, Qiwei Shan, Yi Zhang, Jinxing Liu et al.
doi:10.1038/nbt.2969
TALEN-induced mutation of all homologous copies of a gene that represses resistance to an important wheat pathogen confers a trait that has eluded plant breeders for decades.

See also: News and Views by Gil-Humanes & Voytas

Errata

Erratum: HIV immunity goes direct   p952
doi:10.1038/nbt0914-952a

Erratum: University biotech patenting 2013   p952
Brady Huggett and Kathryn Paisner
doi:10.1038/nbt0914-952b

Erratum: In Their Words   p952
doi:10.1038/nbt0914-952c

Corrigendum

Corrigendum: Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype   p952
Hao Yin, Wen Xue, Sidi Chen, Roman L Bogorad, Eric Benedetti et al.
doi:10.1038/nbt0914-952d

Careers and Recruitment

Top

Mobility, retention and productivity of genomics scientists in the United States   pp953 - 958
Kenneth Guang-Lih Huang and Gokhan Ertug
doi:10.1038/nbt.3016
The United States appears to have an increasingly weakening ability to attract and retain genomics scientists.

People

People   p960
doi:10.1038/nbt.3024

Top Advertisement

Wellcome Trust and Nature Genetics present: The Genomics of Common Diseases 2014 September 17-20, 2014 Bolger Center, Potomac, MD, USA Click here for more information to register for this conference today!

 

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You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/myaccount (You will need to log in to be recognised as a nature.com registrant) For further technical assistance, please contact our registration department For print subscription enquiries, please contact our subscription department For other enquiries, please contact our customer feedback department Nature Publishing Group | 75 Varick Street, 9th Floor | New York | NY 10013-1917 | USA Nature Publishing Group's worldwide offices: London - Paris - Munich - New Delhi - Tokyo - Melbourne San Diego - San Francisco - Washington - New York - Boston Macmillan Publishers Limited is a company incorporated in England and Wales under company number 785998 and whose registered office is located at Brunel Road, Houndmills, Basingstoke, Hampshire RG21 6XS. © 2014 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.